Binding properties of mono- and dimeric pyridine dicarboxamide ligands to human telomeric higher-order G-quadruplex structures - MNHN - Muséum national d'Histoire naturelle Access content directly
Journal Articles Chemical Communications Year : 2018

Binding properties of mono- and dimeric pyridine dicarboxamide ligands to human telomeric higher-order G-quadruplex structures

Abstract

Here, we report on the in vitro binding properties of the known pyridine dicarboxamide G-quadruplex ligand 360A and a new dimeric analogue (360A)2A to human telomeric DNA higher-order G-quadruplex (G4) structures. This study points to original binding features never reported for G4 ligands, and reveals a greater efficiency for the dimeric ligand to displace RPA (a ssDNA binding protein involved in telomere replication) from telomeric DNA.
Fichier principal
Vignette du fichier
Saintome ChemComm 2018.pdf (3.23 Mo) Télécharger le fichier
Origin : Files produced by the author(s)
Loading...

Dates and versions

mnhn-02308805 , version 1 (08-10-2019)

Identifiers

Cite

C. Saintomé, Patrizia Alberti, N. Guinot, P. Lejault, J. Chatain, et al.. Binding properties of mono- and dimeric pyridine dicarboxamide ligands to human telomeric higher-order G-quadruplex structures. Chemical Communications, 2018, 54 (15), pp.1897-1900. ⟨10.1039/c7cc07048a⟩. ⟨mnhn-02308805⟩
90 View
217 Download

Altmetric

Share

Gmail Facebook X LinkedIn More