Aminocyclopropanes as precursors of endoperoxides with antimalarial activity - MNHN - Muséum national d'Histoire naturelle Access content directly
Journal Articles Organic & Biomolecular Chemistry Year : 2010

Aminocyclopropanes as precursors of endoperoxides with antimalarial activity

Abstract

This contribution describes the synthesis of several novel bicyclic α-amino endoperoxides, including CF3-substituted compounds, prepared by the aerobic electrochemical oxidation of a family of bicyclic aminocyclopropanes. These, in turn, are readily synthesised by a titanium-mediated intramolecular cyclopropanation process (Kulinkovich–de Meijere reaction), starting from N-alkenyl amides that contain a vic-disubstituted double bond, with high diastereoselectivity. An evaluation of the biological activities of several of the molecules produced, against the parasite Plasmodium falciparum, is also presented.

Dates and versions

mnhn-02047403 , version 1 (24-02-2019)

Identifiers

Cite

Claire Madelaine, Olivier Buriez, Benoit Crousse, Isabelle Florent, Philippe Grellier, et al.. Aminocyclopropanes as precursors of endoperoxides with antimalarial activity. Organic & Biomolecular Chemistry, 2010, 8 (24), pp.5591. ⟨10.1039/c0ob00308e⟩. ⟨mnhn-02047403⟩
68 View
0 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More