Monocrystalline diamond detector for online monitoring during synchrotron microbeam radiotherapy - WP1: Méthodes et instrumentations innovantes en radiothérapies Accéder directement au contenu
Pré-Publication, Document De Travail (Preprint/Prepublication) Année : 2023

Monocrystalline diamond detector for online monitoring during synchrotron microbeam radiotherapy

Résumé

Microbeam Radiation Therapy (MRT) is a radiotherapy technique combining spatial fractionation of the dose distribution at a micrometric scale, x-rays in the 50-500 keV range, and doserates up to 16×10 3 Gy/s. Nowadays, in-vivo dosimetry remains a challenge due to the ultra-high radiation fluxes and the need for high spatial resolution detectors. Our aim was to develop a striped diamond portal detector enabling on-line microbeam monitoring during synchrotron MRT treatments. The detector, a 550 µm bulk monocrystalline diamond, was an 8-strip device, having 3 mm high, 178 µm wide, and 60 µm spaced strips, surrounded by a guard ring. An 8-channel ASIC circuit for charge integration and digitization was designed and tested. Characterization tests were performed at the ID17 Biomedical beamline of the European Synchrotron Radiation Facility (ESRF). The detector measured direct and attenuated microbeams as well as interbeam fluxes with a 1% precision level. Phantoms' tests (RW3 and anthropomorphic head phantoms) were performed and compared to simulations. Measurements under synchrotron radiation were performed on the RW3 phantom for strips facing a microbeam, and an interbeam area. Differences between experiments and simulations resulted of 2%. In more complex geometries, a preliminary study showed that absolute differences between simulated and recorded transmitted beams were within 2%. Obtained results showed the feasibility of performing MRT portal monitoring using a microstriped diamond detector. Currently, online dosimetric measurements are ongoing during clinical veterinary trials at ESRF, and the next 153-strip detector prototype, covering the entire irradiation field, is under finalization in our institution.
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Dates et versions

hal-04323368 , version 1 (25-09-2023)
hal-04323368 , version 2 (06-12-2023)

Identifiants

  • HAL Id : hal-04323368 , version 1

Citer

Francesca Di Franco, Nicolas Rosuel, Laurent Gallin-Martel, Marie-Laure Gallin-Martel, Mostafa Ghafooryan-Sangchooli, et al.. Monocrystalline diamond detector for online monitoring during synchrotron microbeam radiotherapy. 2023. ⟨hal-04323368v1⟩
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