%0 Journal Article %T Cilia-mediated Hedgehog signaling controls form and function in the mammalian larynx %+ Department of Molecular Biosciences [Austin, TX, USA] %+ Department of Biology [Atlanta, GA, USA] %+ Cellules Souches et Développement / Stem Cells and Development %+ Département Adaptations du vivant (AVIV) %+ Department of Craniofacial Development and Stem Cell Biology [London, UK] %+ Janelia Farm Research Campus %A Tabler, Jacqueline %A Rigney, Maggie %A Berman, Gordon %A Gopalakrishnan, Swetha %A Heude, Eglantine %A Al-Lami, Hadeel Adel %A Yannakoudakis, Basil %A Fitch, Rebecca %A Carter, Christopher %A Vokes, Steven %A Liu, Karen, J. %A Tajbakhsh, Shahragim %A Egnor, S.E Roian %A Wallingford, John %Z This work was supported by an NRSA to JT from the NIDCR (F32DE023272); funding to ST from the Institut Pasteur, Association Française contre le Myopathies, and Agence Nationale de la Recherche (Laboratoire d’Excellence Revive, Investissement d’Avenir; ANR-10-LABX-73); and NIH R01HD073151 to SAV and R01HD085901 to JBW SERE is supported by the Howard Hughes Medical Institute; JBW was once an early career scientist of the HHMI. %Z Comment in "Shaping the sound of voice. [Elife. 2017]"Jacqueline M Tabler and Maggie M Rigney contributed equally to this work. %< avec comité de lecture %J eLife %I eLife Sciences Publication %V 6 %P e19153 %8 2017-02-13 %D 2017 %R 10.7554/eLife.19153 %M 28177282 %K CPLANE %K Fuz %K cilia %K ciliopathy %K developmental biology %K larynx %K mouse %K neural crest %K stem cells %Z Life Sciences [q-bio]/Animal biology %Z Life Sciences [q-bio]/Cellular Biology %Z Life Sciences [q-bio]/Development Biology %Z Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE] %Z Life Sciences [q-bio]/Genetics %Z Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biologyJournal articles %X Acoustic communication is fundamental to social interactions among animals, including humans. In fact, deficits in voice impair the quality of life for a large and diverse population of patients. Understanding the molecular genetic mechanisms of development and function in the vocal apparatus is thus an important challenge with relevance both to the basic biology of animal communication and to biomedicine. However, surprisingly little is known about the developmental biology of the mammalian larynx. Here, we used genetic fate mapping to chart the embryological origins of the tissues in the mouse larynx, and we describe the developmental etiology of laryngeal defects in mice with disruptions in cilia-mediated Hedgehog signaling. In addition, we show that mild laryngeal defects correlate with changes in the acoustic structure of vocalizations. Together, these data provide key new insights into the molecular genetics of form and function in the mammalian vocal apparatus. %G English %2 https://mnhn.hal.science/mnhn-02295443/document %2 https://mnhn.hal.science/mnhn-02295443/file/elife-19153-v4.pdf %L mnhn-02295443 %U https://mnhn.hal.science/mnhn-02295443 %~ INSERM %~ PASTEUR %~ MNHN %~ CNRS %~ GIP-BE %~ ANR %~ ALLIANCE-SU %~ UMR3738 %~ STEM-CELLS-DEVELOPMENT