Novel N-(4-Piperidinyl)benzamide Antimalarials with Mammalian Protein Farnesyltransferase Inhibitory Activity - MNHN - Muséum national d'Histoire naturelle Access content directly
Journal Articles Chemical and Pharmaceutical Bulletin Year : 2005

Novel N-(4-Piperidinyl)benzamide Antimalarials with Mammalian Protein Farnesyltransferase Inhibitory Activity

Abstract

Protein farnesyltransferase of Plasmodium falciparum is a potential target in the treatment of malaria for which increased drug resistance is observed. The design, synthesis and evaluation of a series of N-(4-piperidinyl)benzamides is reported. The most potent compounds showed in vitro activity against the parasite at submicromolar concentrations.
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mnhn-02070112 , version 1 (16-03-2019)

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A Ryckebusch, Pauline Gilleron, R Millet, R Houssin, A Lemoine, et al.. Novel N-(4-Piperidinyl)benzamide Antimalarials with Mammalian Protein Farnesyltransferase Inhibitory Activity. Chemical and Pharmaceutical Bulletin, 2005, 53 (10), pp.1324-1326. ⟨10.1248/cpb.53.1324⟩. ⟨mnhn-02070112⟩

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