%0 Journal Article
%T Sesquiterpenoids from Teucrium ramosissimum
%+ Molécules de Communication et Adaptation des Micro-organismes (MCAM)
%A Henchiri, H
%A Bodo, B
%A Deville, A
%A Dubost, L
%A Zourqui, L
%A Raies, A
%A Grellier, Philippe
%A Mambu, Lengo
%< avec comité de lecture
%@ 0031-9422
%J Phytochemistry
%I Elsevier
%V 70
%N 11-12
%P 1435-1441
%8 2009-07
%D 2009
%R 10.1016/j.phytochem.2009.08.012
%K Teucrium ramosissimum
%K Lamiaceae
%K Sesquiterpenoids
%K Trinorsesquiterpenoids
%K Antiplasmodial activity
%Z Chemical Sciences
%Z Life Sciences [q-bio]
%Z Life Sciences [q-bio]/Microbiology and ParasitologyJournal articles
%X An antiplasmodial bioguided investigation of the EtOAc extract of the aerial parts of Teucrium ramosissimum led to isolation and identification of three sesquiterpenoids, teucmosin, 4α-hydroxy-homalomenol C, 1β,4β,7α-trihydroxy-8,9-eudesmene and two trinorsesquiterpenoids, 4β-hydroxy-11,12,13-trinor-5-eudesmen-1,7-dione and 1β,4β-dihydroxy-11,12,13-trinor-8,9-eudesmen-7-one together with five known sesquiterpenoids, oplopanone, homalomenol C, oxo-T-cadinol, 1β,4β,6β-trihydroxyeudesmane, 1β,4β,7α-trihydroxyeudesmane and four flavonoids, 5-hydroxy-7,4′-dimethoxyflavone, salvigenin, genkwanin and cirsimaritin. The structures and the relative stereochemistry were elucidated by extensive spectroscopic studies including 1D and 2D NMR and mass spectrometry (MS). Homalomenol C, 4β-hydroxy-11,12,13-trinor-5-eudesmen-1,7-dione, oxo-T-cadinol and 1β,4β,6β-trihydroxyeudesmane displayed a significant in vitro antiplasmodial activity against Plasmodium falciparum with IC50 values ranging from 1.2 to 5.0 μg/ml. Furthermore, no cytotoxicity was observed upon the human diploid lung cell line MRC-5 for these compounds.
%G English
%L mnhn-02070076
%U https://mnhn.hal.science/mnhn-02070076
%~ MNHN
%~ CNRS
%~ ALLIANCE-SU