%0 Journal Article %T Sesquiterpenoids from Teucrium ramosissimum %+ Molécules de Communication et Adaptation des Micro-organismes (MCAM) %A Henchiri, H %A Bodo, B %A Deville, A %A Dubost, L %A Zourqui, L %A Raies, A %A Grellier, Philippe %A Mambu, Lengo %< avec comité de lecture %@ 0031-9422 %J Phytochemistry %I Elsevier %V 70 %N 11-12 %P 1435-1441 %8 2009-07 %D 2009 %R 10.1016/j.phytochem.2009.08.012 %K Teucrium ramosissimum %K Lamiaceae %K Sesquiterpenoids %K Trinorsesquiterpenoids %K Antiplasmodial activity %Z Chemical Sciences %Z Life Sciences [q-bio] %Z Life Sciences [q-bio]/Microbiology and ParasitologyJournal articles %X An antiplasmodial bioguided investigation of the EtOAc extract of the aerial parts of Teucrium ramosissimum led to isolation and identification of three sesquiterpenoids, teucmosin, 4α-hydroxy-homalomenol C, 1β,4β,7α-trihydroxy-8,9-eudesmene and two trinorsesquiterpenoids, 4β-hydroxy-11,12,13-trinor-5-eudesmen-1,7-dione and 1β,4β-dihydroxy-11,12,13-trinor-8,9-eudesmen-7-one together with five known sesquiterpenoids, oplopanone, homalomenol C, oxo-T-cadinol, 1β,4β,6β-trihydroxyeudesmane, 1β,4β,7α-trihydroxyeudesmane and four flavonoids, 5-hydroxy-7,4′-dimethoxyflavone, salvigenin, genkwanin and cirsimaritin. The structures and the relative stereochemistry were elucidated by extensive spectroscopic studies including 1D and 2D NMR and mass spectrometry (MS). Homalomenol C, 4β-hydroxy-11,12,13-trinor-5-eudesmen-1,7-dione, oxo-T-cadinol and 1β,4β,6β-trihydroxyeudesmane displayed a significant in vitro antiplasmodial activity against Plasmodium falciparum with IC50 values ranging from 1.2 to 5.0 μg/ml. Furthermore, no cytotoxicity was observed upon the human diploid lung cell line MRC-5 for these compounds. %G English %L mnhn-02070076 %U https://mnhn.hal.science/mnhn-02070076 %~ MNHN %~ CNRS %~ ALLIANCE-SU