A New Xanthone from the Bark Extract of Rheedia acuminata and Antiplasmodial Activity of Its Major Compounds

Bioassay-guided fractionation of the ethyl acetate bark extract of Rheedia acuminata led to the isolation of the new compound 1,5,6-trihydroxy-3-methoxy-7-geranyl-xanthone (1), together with four known compounds 2-5. These compounds were tested in vitro for their antiplasmodial activity on a chloroquine-resistant strain of Plasmodium falciparum (FcB1) and for their cytotoxicity against the human diploid embryonic lung cell line MRC-5.

Mots clés

cytotoxicity antiplasmodial activity Rheedia acuminata Clusiaceae xanthones

Domaines

Sciences du Vivant [q-bio] Microbiologie et Parasitologie Chimie organique

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molecules-15-07106.pdf (204.73 Ko)

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https://mnhn.hal.science/mnhn-02047400

Soumis le : dimanche 24 février 2019-16:17:47

Dernière modification le : jeudi 18 juillet 2024-10:52:21

Archivage à long terme le : samedi 25 mai 2019-12:44:33

Dates et versions

mnhn-02047400 , version 1 (24-02-2019)

Identifiants

HAL Id : mnhn-02047400 , version 1
DOI : 10.3390/molecules15107106
PUBMED : 20948498

Citer

Guillaume Marti, Véronique Eparvier, Marc Litaudon, Philippe Grellier, Francoise Guéritte. A New Xanthone from the Bark Extract of Rheedia acuminata and Antiplasmodial Activity of Its Major Compounds. Molecules, 2010, 15 (10), pp.7106-7114. ⟨10.3390/molecules15107106⟩. ⟨mnhn-02047400⟩

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IRD MNHN CNRS ICSN INC-CNRS UNIV-PARIS-SACLAY PHARMA-DEV GS-HEALTH-DRUG-SCIENCES TOULOUSE-INP UNIV-UT3 UT3-TOULOUSEINP

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