Designing new input devices and associated interaction techniques is a key contribution in order to increase the bandwidth between users and interactive applications. In the field of Human-Computer Interaction, research and development services in industry and research laboratories in universities have been, since the invention of the mouse and the graphical user interface, proposing multiple contributions including the integration of multiple input devices in multimodal interaction technique. Those contributions, most of the time, are presented as prototypes or demonstrators providing evidence of the bandwidth increase through user studies. Such contributions however, do not provide any support to software developers for integrating them in real-life systems. When done, this integration is performed in a craft manner, outside required software engineering good practice. This paper proposes a systematic process to integrate novel input devices and associated interaction techniques to better support users' work. It exploits most recent interactive systems architectural model and formal model-based approaches for interactive systems supporting verification and validation when required. The paper focusses on Frame-based input devices which support gesture-based interactions and movements recognition but also addresses their multimodal use. This engineering approach is demonstrated on an interactive application in the area of rehabilitation in healthcare where dependability of interactions and applications is as critical as their usability.