Click and Collect at high resolution to unlock the secrets of cell wall synthesis
Résumé
The peptidoglycan is a three-dimensional sugar and peptide network that surrounds the bacterial cell. It confers a cell shape adapted to the ecological niche of the bacterium and protects it against mechanical stresses. Peptidoglycan synthesis and integrity are thus essential for bacterial proliferation and survival. Despite the importance of these fundamental processes, which constitute sources of antibiotic targets, we still poorly understand how the peptidoglycan is assembled and remodeled in space and time to ensure proper cell division, shape and integrity. This is particularly true for ovoid-shaped bacteria such as streptococci and enterococci, in which two different modes of peptidoglycan synthesis, dedicated to cell division and elongation, are confined to an annular region with nanometric dimensions at midcell.
Domaines
Sciences du Vivant [q-bio]Origine | Fichiers produits par l'(les) auteur(s) |
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